With pyroluria, some of the by-products of the synthesis of haemoglobin called kryptopyrroles are produced in excess by the liver and not fully excreted in the urine. These kryptopyrroles are normally harmless. However, if the HPL in your body builds up to an excessive level, the HPL binds to zinc and vitamin B6, and also blocks the receptor sites for these two nutrients. The HPL-zinc-B6 complex is then excreted in the urine. The result is major deficiency in Vitamin B6 and Zinc, and to a lesser degree in other nutrients such as gamma linolenic acid (GLA), niacinamide, biotin, and sometimes manganese and other B-vitamins.
The deficiency in zinc and B6 is so large that it cannot be counterbalanced by foods high in these two nutrients. Zinc and B6 are critical nutrients for producing all proteins including enzymes, hormones and neurotransmitters required by all organs, muscle and connective tissue. This shortage affects the functioning of your entire body and mind, including immune system, digestion, cognitive functioning, energy production, muscle mass and emotions.